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Professor Daniel Sifrim

Professor Daniel Sifrim

Clinical Special Interests:

Upper gastro-intestinal functional disorders including:
1. Gastro-oesophageal reflux disease
2. Oesophageal motility disorders (i.e. achalasia)
3. Aerophagia and belching disorders
4. Dyspepsia, gastroparesis and rumination syndrome 


The Princess Grace Hospital, Outpatients Department, 47 Nottingham Place, W1U 5LZ



+44 (0) 20 7034 5020


Professor Daniel Sifrim completed his medical training in 1979 at the Buenos Aires University, Argentina. He did his Internal Medicine and Gastroenterology training at the Posadas General Hospital, in Buenos Aires. In 1990 he moved to Belgium for specialised training in gastro-intestinal motility. He was a research fellow at the Center for Gastroenterological Research at the University of Leuven, Belgium and he obtained a PhD degree in 1994 under the supervision of Prof. dr. G. Vantrappen. From 1994 - 2008, Prof Sifrim developed his clinical research and academic career in Belgium. He was appointed first Associate Professor and later full Professor of Medicine at the University of Leuven. In 2009, Prof Sifrim was appointed Professor of Gastrointestinal Physiology at Barts and The London School of Medicine and Dentistry at Queen Mary, University of London. His research focuses on the physiology and pathophysiology of oesophageal motility and gastro-oesophageal reflux disease. Prof Sifrim has been devoted to the development of new techniques to measure oesophageal motility and gastroesophageal reflux. He serves as a reviewer for most of the gastroenterology journals and has authored or co-authored more than 150 original articles, book chapters and reviews on oesophageal disorders. He received the American Gastroenterology Association, Janssen Award 2003 for Basic and Clinical Research.

Summary of key research areas

1) in vitro studies on changes in oesophageal mucosa permeability due to stress or exposure to bile acids

2) in vivo animal studies on pharmachology of the lower oesophageal sphincter and TLESRs; analysis of the relationship between oesophageal inflammation and motility; the physiology of the oesophageal longitudinal muscle layer and oesophageal shortening

3) physiological studies in healthy human subjects on the role of inhibitory mechanisms in the regulation of primary and secondary peristalsis; the relationship between inhibition in the oesophageal body and TLESRs; measurements of tone in the oesophageal body; pharmachological studies on TLESRs and reflux

4) studies in patients with primary oesophageal motor disorders defining the role of incomplete inhibitory mechanisms in the pathophysiology of diffuse spasm and achalasia; studies in patients with GERD characterizing different types of reflux (acid and non-acid) during TLESRs; analysis of the composition of reflux using impedance pH monitoring both in stationary and ambulatory conditions; analysis of the role of non-acid and gas reflux in patients with refractory GERD and NERD; analysis of the role of ineffective motility in the oesophageal body both for oesophageal clearance and perception of dysphagia; analysis of the role of gastric emptying in the determination of frequency and type of reflux; pharmachological studies on TLESRs and acid and non-acid reflux; analysis of the relationship between GER and respiratory disorders like unexplained chronic cough, lung transplant and cystic fibrosis.

Daniel Sifrim is professor of Gastrointestinal Physiology and coordinates both undergraduate   and postgraduate courses on GI physiology and pathophysiology.